Trenbolone increases nitrogen retention in muscle tissue .
The drug Trenbolone is, without a doubt, the most powerful injectable anabolic steroid used by Steroid.com members to gain muscle. However the full properties of the drug are not always fully understood. This profile will separate fact from fiction and help steroid.com members decide if Trenbolone is right for them.
Trenbolone is similar to the highly popular steroid Nandrolone, in that they are both 19-nor steroids, meaning that a testosterone molecule has been altered at the 19th position to give us a new compound. Unlike Nandrolone however Trenbolone is an excellent mass and hardening drug with the majority of gains being muscle fiber, with minimal water retention (1) It has an unbelievable anabolic (muscle building) score of 500. When you compare that to Testosterone, which itself is a powerful mass builder, and has an anabolic score of 100 you can begin to fathom the muscle building potential of Trenbolone. What makes Trenbolone so anabolic? Numerous factors come into play. Trenbolone greatly increases the level of the extremely anabolic hormone IGF-1 within muscle tissue (2). And, its worth noting that not only does it increase the levels of IGF-1 in muscle over two fold, it also causes muscle satellite cells (cells that repair damaged muscle) to be more sensitive to IGF-1 and other growth factors(3). The amount of DNA per muscle cell may also be significantly increased (3).
Trenbolone also has a very strong binding affinity to the androgen receptor (A.R), binding much more strongly than testosterone (4). This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating A.R dependent mechanisms of muscle growth. There is also strong supporting evidence that compounds which bind very tightly to the androgen receptor also aid in fat loss. Think as the receptors as locks and androgen's as different keys, with some keys (androgen's) opening (binding) the locks (receptors) much better than others. This is not to say that AR-binding is the final word on a steroids effectiveness. Anadrol doesnt have any measurable binding to the AR& and we all know how potent Anadrol is for mass-building.
Trenbolone increases nitrogen retention in muscle tissue (5). This is of note because nitrogen retention is a strong indicator of how anabolic a substance is. However, it's incredible mass building effects do not end there. Trenbolone has the ability to bind with the receptors of the anti-anabolic (muscle destroying) glucocorticoid hormones (6). This may also has the effect of inhibiting the catabolic (muscle destroying) hormone cortisol (7).
Yet another amazing trait that must be noted is its ability to improve feed efficiency and mineral absorption in animals given the drug (8). To help you understand what this means for you, feed efficiency is a measurement of how much of an animals diet is converted into meat, and the more food it takes to produce this meat, the lower the efficiency. Conversely, the less food it takes to produce meat the, higher the efficiency& well you get the idea. Animals given Trenbolone gained high quality weight without having their diet adjusted, thus improving feed efficiency. Finding new compounds which can improve feed efficiency is a billion dollar industry, and has spawned many nutritional advances in the bodybuilding world over the last few decades (CLA, Whey Protein, and HMB are compounds which spring to mind as having first been introduced by the livestock industry). What does this translate to for the hard training athlete? The food you eat will be better utilized for building lean muscle, and vitamins and minerals are also better absorbed which may keep you healthier during cycle.
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Trenbolone is also a highly androgenic hormone, when compared with Testosterone, which has an androgenic ratio of 100; Trenbolone's androgenic ratio is an astonishing 500. Highly androgenic steroids are appreciated for the effects they have on strength as well as changing the estrogen/androgen ratio, thus reducing water and under the skin. As if the report on Trenbolone was not good enough, it gets better; Trenbolone is extraordinarily good as a fat loss agent. One reason for this is its powerful effect on nutrient partitioning (9). It is a little known fact is that androgen receptors are found in fat cells as well as muscle cells(10), androgens act directly on the A.R in fat cells to affect fat burning.(11) the stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose tissue (fat)(11). Since some steroids even increase the numbers of A.R in muscle and fat (11, 12) this fat loss effect would be amplified with the concurrent use of other compounds, such as Testosterone.
Trenbolone promotes red blood cell production and increases the rate of glycogen replenishment, significantly improving recovery (13). Like almost all steroids, it's effects are dose dependant with higher dosages having the greatest effects on body composition and strength. Mental changes are a notorious side effect of Trenbolone use (15), androgens increase chemicals in the brain that promote aggressive behavior(16), which can be beneficial for some athletes wanting to improve speed and power.
Trenbolone's chemical structure makes it resistant to the aromatize enzyme (conversion to estrogen) thus absolutely no percentage of Trenbolone will convert to estrogen. Trenbolone administration would not promote estrogenic side effects such as breast tissue growth in men (gynecomastia, bitch tits) accelerated fat gain, decline in fat break down and water retention. Trenbolone is also resistant to the 5- alpha-reductase enzyme, this enzyme reduces some steroid hormones into a more androgenic form, in this case however this does not matter. Trenbolone boasts an androgenic ratio of 500. It can easily cause adverse androgenic side effects in people who are prone to hair loss, prostate enlargement, oily skin and acne. Unfortunately Trenbolone's potential negative side effects do not end there. Trenbolone is also a noted progestin: it binds to the receptor of the female sex hormone progesterone (with about 60% of the actual strength progesterone) (17). In sensitive people this can lead to bloat and breast growth worse still, Trenbolone's active metabolite 17beta-trenbolone has a binding affinity to the progesterone receptor (PgR) that is actually greater than progesterone itself (18). No need to panic though, the anti-estrogens letrzole or fulvestrant can lower progesterone levels, and combat any progestenic sides. The use of a 19-nor compound like trenbolone also increases prolactin & . bromocriptine or cabergoline are often recommended to lower prolatin levels (20). Testicular atrophy (shrunken balls) may also occur; HCG used intermittently throughout a cycle can prevent this. (21) It is also wise for Tren users to closely monitor their cholesterol levels, as well as kidney function and liver enzymes, as Tren has the potential to negatively affect all of those functions. Finaplix, being a powerful progestin, will also shut down natural testosterone production which even a relatively small dose and keep the testosterone level suppressed for an extended period of time, this can lower libido and cause erectile dysfunction (fina dick). It is essential that you always stack Finaplix with testosterone.
The acetate ester is a very short-chain ester attached to the Finaplix molecule. It has an active life of 2-3 days but to keep blood levels of trenbolone elevated and steady, daily injections are often recommended. The acetate ester provides a rapid and high concentration of the hormone which is beneficial to those seeking quick gains, coupled with a rapid clearing time the acetate ester can be discontinued on the onset of adverse side effects.
Now that the properties of Trenbolone Acetate have been explained we can better understand how to use it in order to maximize its advantages. Evidence suggests that Finaplix when stacked with estrogen promotes more weight gain that Trenbolone alone(22), now Im not telling you to go pop some birth control with your Tren but the addition of aromatizing orals such as Dianabol and a long estered testosterone such as Cypionate or Enanthate would produce great gains in a bulking cycle. For a cutting cycle Finaplix is the best choice you have; Trenbolone's powerful effect on nutrient shuttling allows a user to restrict calories and remain in a state of positive nitrogen balance (remember what that means?). The cortisol reducing effect and binding to the glucocorticoid receptor will greatly reduce the catabolic effects of harsh dieting and excessive amounts of cardio and not to mention that Finaplix itself may burn fat (due to its strong AR-binding). A good choice to stack with Tren in a cutting cycle is Winstrol. Winstrol has a low binding affinity to the AR and thus will act in your body in vastly different ways than the Tren (i.e. in non-receptor mediated action). In addition, Winstrol is a DHT-based drug and Tren is a 19-nor& throw in some Testosterone (prop), and you'll have a cutting cycle which takes advantage of all 3 major families of Anabolic Steroids (Testosterone, 19-nor, and DHT), as well as vastly different AR-binding affinities and mechanisms of action.
Ironically, even though Trenbolone ( Tren ) is an excellent contest prep drug, it lowers your thyroid level(23), and this raises prolactin. I recommend taking T3 (25mcgs/day) along with your Tren to avoid elevating your prolactin too high via this route.
Also, this drug is a poor choice for athletes who rely on cardiovascular fitness to play a sport. Trenbolone ( Tren ), anecdotally at least, reduces many athletes ability to sustain high levels of endurance. Unfortunately, this makes Tren a poor choice for many.
As of now the main source of Trenbolone is from implants for cattle being converted into an injectable or transdermal compound, from powder, and of course Underground Labs. "Home brewing" powder or cattle implants seems to be the preferred method of obtaining injectable Trenbolone Acetate, because the user would have much more control over the potency and sterility of the drug. Trenbolone is much more expensive than other anabolic steroids ranging from 15 U.S dollars per gram of powder or 150 U.S for a single 10 ml bottle. The cost of Trenbolone should not matter, it is worth every penny.
Trenbolone Acetate Profile
(Trenbolone Base + Acetate Ester)
Formula: C20 H24 O3
Molecular Weight: 312.4078
Molecular Weight (base): 270.3706
Molecular Weight (ester):60.0524
Formula (base): C18 H22 O2
Formula (ester): C2 H4 O2
Melting Point (base): 183-186C
Melting Point (ester):16.6C
Manufacturer: Cattle implants, British Dragon, Various
Effective Dose (Men):50-150mg ED
Effective Dose (Women): Not recommended
Active life: 2-3 days
Detection Time: 5 months
Anabolic/Androgenic ratio: 500/500
A good Trenbolone cycle can be one of the best cycles any performance enhancer will ever complete and while there are many forms and plans to choose from disappointment is rarely a concern you will have. As it is the easiest to control and the most widely available Trenbolone Acetate will be our preferred and recommended Tren form; it is not a must, you can use Trenbolone-Enanthate or Trenbolone- Hexahydrobencylcarbonate (Parabolan) if you so choose but the Acetate form is generally the most efficient. As you may already understand a Trenbolone cycle can be during a period of growth or dieting and in most cases it is equally effective in both; in-fact, it is such an amazing steroid many performance enhancers choose to include it in most of their cycles regardless of purpose.
The Basic Trenbolone Cycle:
While it may be a basic Trenbolone cycle that by no means implies that it is weak but this will be a good place for a first time Tren user to start and in many cases it will be as extensive as many will ever need to go. Your basic Trenbolone cycle will always include testosterone; in-fact we must recommend testosterone with all Trenbolone cycles as the Tren hormone is very suppressive to natural testosterone production; so much so that without testosterone therapy you would have no testosterone in play.
For this Trenbolone cycle our dosing will be at 50mg every other day; if you tolerate that dosing well and still want more 75mg every other day can be well justified. In most cases, regardless of the specific dose the total duration of use will be for 8 weeks; 12 weeks can be used but 8 is far more tolerable by most and in the name of health generally a good place to end. If you are going to enter the 12 week mark of use it is generally better to have some experience with the hormone and to be practicing such methods for very specific purposes such as a competition. For the off-season Trenbolone cycle you will find it stacks very well with testosterone and Dianabol as well as Anadrol if you so choose. During your cutting phase Tren will stack well again with testosterone and other anabolics such as Winstrol and Anavar.
Advanced Trenbolone Cycle:
An advanced Trenbolone cycle will always begin at 100mg every other day and often and in many cases creep its way into dosing levels of 100mg every single day during use. Such every day doses are generally not needed for the off-season athlete; such doses are not going to create enough added growth to warrant the added physical stress; however, daily doses of 100mg per day can be very useful during a diet, particularly later on in the diet close to a competition.
For the off-season advanced Trenbolone cycle of 100mg every other day many will find a combo of Test/Tren/Dbol to be just about unbeatable but for the truly advanced users we at many times recommend an overlapping method. For an effective overlapping Trenbolone cycle the individual might supplement with testosterone and Deca-Durabolin for 12 weeks but at the 10 week mark he would have added in Tren to the equation and by week 12 discontinued his Deca and stuck with Tren and Testosterone only. An overlapping Trenbolone cycle might look like this (example does not include orals such as Dianabol or Anadrol):
Week 1-20 Testosterone
Week 1-12 Deca-Durabolin
Week 10-20 Trenbolone
For the dieting or cutting Trenbolone cycle this is where things can get really exciting as the choices are truly endless. In most cases you will be best served by supplementing with your Tren the latter half of the dieting phase; for example, if you are going to diet for 16 weeks you will want to use the Tren the last 8-12 weeks rather than from the start. You can also use the same overlapping method here as well; many athletes enjoy a Trenbolone cycle that overlaps with Equipoise during this period of use. As for other items, Winstrol, as always testosterone, good AIs and fat burners and if you can swing it a good batch of HGH and youll have a cycle that's hard to beat.
For the performance enhancing athlete there are so many choices and options and while many of these options have a place in just about any cycle there are very few that do in such a true and versatile way. Trenbolone is one of these anabolic steroids as positive Trenbolone effects are so pronounced in a variety of ways throughout the body. Of course it cannot be denied, the adverse Trenbolone effects can be quite brutal and for many men this makes it an anabolic steroid they absolutely cannot use; however, the majority can tolerate it quite well and if you happen to be one of these you will not find a better choice for your performance enhancing needs.
Primary Trenbolone Effects:
Many of the primary Trenbolone effects are very similar to many other anabolic steroids, especially testosterone; however, within each one the level of effectiveness, the level of power in-which each effect is displayed, is far greater. The primary Trenbolone effects include:
Increased IGF-1 Production
Increased Nitrogen Retention in the Muscles
Increased Protein Synthesis
Increased Red Blood Cell Count
Decrease in Glucocorticoid Steroid Production
All of these functions can lead to a more muscular and stronger physique as well as have a very strong and positive effect on the individuals metabolic rate. Of course a logical question might be how truly powerful is this hormone? The positive Trenbolone effects are so powerful that when we compare its anabolic and androgenic nature to testosterone we find that it is both 500 times more anabolic and 500 times more androgenic and you already know how powerful testosterone is so do the math and its easy to see you have one amazing hormone in Tren.
Bonus Trenbolone Effects:
If the above effects werent already enough there is one that really sets Tren apart and it is nutrient efficiency. The Trenbolone hormone has been shown to greatly increase nutrient efficiency meaning the very food you eat becomes more valuable. Due to the simple nature of this hormones existence our body is able to utilize each and every gram of food we eat to a higher degree; if our body is a factory the level of productive output simply goes up. Why is this important? The reason is simple, food is the most anabolic substance we put in our body and the more efficiently we can utilize each and every nutrient the more efficient our entire performance process will be; of all the Trenbolone effects this may indeed be the most important one.
Adverse Trenbolone Effects:
Tren is not without its problems; it truly is a remarkable steroid but as it is so powerful, as is common with powerful steroids the negative side-effects can be a little strong. Thankfully of the negative Trenbolone effects aromatase is not one of them, making excess water retention no concern at all; however, while it does not aromatize Gynecomastia can still occur due to Tren being of a high progestin nature; for those sensitive to Gynecomastia a good aromatase inhibitor is advised. Trenbolone can also increase blood pressure quite significantly and can lead to hair-loss in men who are genetically predisposed, meaning you were going to go bald anyway the Tren just sped it up. Blood pressure can normally be controlled in healthy men who eat a proper diet and exercise regularly. If you are predisposed to high blood pressure you may want to avoid the Trenbolone hormone and if you already have high blood pressure there is no way on earth you should ever touch it.
As you can see these adverse Trenbolone effects are so far fairly mild and easy to control but were not quite out of the water yet. There is a list of adverse Trenbolone effects that can be very strong and they include:
Rapid Heart Rate
Loss of Libido
In most cases one or more of these effects will be noticed by all users to at least a slight degree, especially insomnia and excess sweating but heart rate issue will prove to be very individualistic based on individual sensitivity. These are the Trenbolone effects that can be very brutal, for if they exist they can exist in a far more pronounced manner than you have ever experienced. For many men they can become too much and for this reason it is often advised you stick with short ester base Tren such as Trenbolone-Acetate; this way if the side-effects become too much you can discontinue use and have it cleared from your system in about 72 hours; if youre using Trenbolone-Enanthate youll have to wait for over a week. As for libido, in most cases this is easy to control through responsible use; Tren will suppress natural testosterone production dramatically and for this reason testosterone therapy is a must when Tren is being used. Always remember, responsible use is your best friend; if you use responsibly the above side-effects while they may still occur the odds will be far more in your favor.
Trenbolone Side Effects
When we look at anabolic steroids we’re always concerned with possible adverse reactions and when it comes to Trenbolone side effects we truly have an anabolic steroid that necessarily deserves a little more respect than normal. The Trenbolone side effects can be somewhat harsh and for many men this is simply a steroid they will not be able to tolerate; that is unfortunate as for the men who can they will not find a better anabolic steroid on earth.
The negative reactions that can occur can largely be broken down into two separate categories, with category 1 largely being similar to many other anabolic steroids and category 2 being a little unique to Tren as it is commonly known. It will undoubtedly be the category 2 Trenbolone side effects that prove to be the most bothersome and it will be these Trenbolone side effects that will prevent many men from ever touching the hormone. Let’s take a look at all the side effects and see what we can do to aid in our favor.
Category 1 Trenbolone Side Effects:
As many of you are aware it is the aromatase process that is responsible for many of the most common anabolic androgenic steroid related side effects and with that in mind we have some good news for you; Trenbolone does not aromatize. For this reason water retention is non-existent with this steroid and for that reason many assume Gynecomastia is too; don’t be fooled. The Tren hormone is of a progestin nature and you can develop some of the most horrific Gynecomastia on earth due to its use. However, like with aromatizing steroids a good aromatase inhibitor will protect you, most notably Arimidex and Letrozole.
Other possible category 1 Trenbolone side effects can include acne, hair-loss and even high blood pressure and we need to speak on each. Hair-loss, this will only occur in men who are predisposed; meaning, you were going to go bald anyway, the Tren just sped up the process. Men who are not predisposed to male pattern baldness will not lose any hair.
Acne; many men don’t want to believe this but the number one reason many men breakout through the use of any anabolic steroid is because their gear is garbage plain and simple. However, some men even with quality gear will still breakout if they are predisposed to acne in the first place. Men who have healthy skin, who keep their skin clean and generally have no acne problems to begin with will not have a problem with this steroid.
Blood pressure; largely in many cases this can be dose dependent; if the dose goes too high so can your blood pressure. Men who use responsibly generally have no blood pressure problems but men who are predisposed to high blood pressure will need to keep an eye on it and in many cases would probably be best served sticking with milder anabolic hormones. Men who already have high blood pressure must necessarily stay away from this steroid.
Category 2 Trenbolone Side Effects:
Category 2 Trenbolone side effects will prove to be the most severe and while they may appear mild on paper there’s something you need to understand; each side effect we will list needs to be viewed in the most enhanced and extreme manner possible. The category 2 Trenbolone side effects are the reasons so many men cannot use this hormone; put simply they can’t handle it, not because they’re not man enough but because the reaction their body has is simply too poor in this regard. Category 2 Trenbolone side effects include:
Rapid Heart Rate
Loss of Libido
Loss of libido and erectile dysfunction; these category 2 Trenbolone side effects are the two that are the most easily preventable as they will only occur if the total Tren dosage gets too high and there is not enough testosterone in the system to meet your physical needs. For this reason, among many others it is recommended you supplement with exogenous testosterone any time you touch the Trenbolone hormone.
The remainder of the category 2 Trenbolone side effects they too can be affected by dose and sometimes controlled but it truly is a tossup. The anxiety attacks for some men can be brutal; the insomnia last for days and the rapid heart rate followed by a sudden drop can be not only scary but something thats simply not good for you either. Unfortunately there is not a lot we can do about these side effects, you will either tolerate the hormone well or you wont; there doesn't appear to be a lot of in-between.
With category 2 Trenbolone side effects in mind this is the reason it is always best to stick with short or small ester based Tren such as Trenbolone-Acetate. If the negative reactions become too strong if you are using a small ester Tren form you can simply discontinue use and your system will be clear of the hormone in a matter of a 2 maybe 3 days. However, if you're supplementing with large ester forms such as Trenbolone-Enanthate and problems arise you can still discontinue use but you're going to be dealing with the problems for as long as 2-3 weeks as it will take this much time for the steroid to begin to clear.
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